Showing posts with label Organic. Show all posts
Showing posts with label Organic. Show all posts

Thursday, September 6, 2007

‘Bringing the Ocean to the World,’ in High-Def


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By WILLIAM YARDLEY
Published: September 4, 2007

SEATTLE — Thousands of miles of fiber-optic cables are strung across the world’s oceans, connecting continents like so many tin cans in this age of critical global communication. So the fact that about 800 more miles of fiber-optic cable will soon thread the sea floor off the coast of the Pacific Northwest might not seem particularly revolutionary. Until you meet John R. Delaney, part oceanographer, part oracle.
“This is a mission to Planet Ocean,” said Mr. Delaney, a professor at the University of Washington. “This is a NASA-scale mission to basically enter the Inner Space, and to be there perpetually. What we’re doing is bringing the ocean to the world.”
Under a $331 million program long dreamed of by oceanographers and being financed by the National Science Foundation, Professor Delaney and a team of scientists from several other institutions are leading the new Ocean Observatories Initiative, a multifaceted effort to study the ocean — in the ocean — through a combination of Internet-linked cables, buoys atop submerged data collection devices, robots and high-definition cameras. The first equipment is expected to be in place by 2009.
A central goal, say those involved, is to better understand how oceans affect life on land, including their role in storing carbon and in climate change; the causes of tsunamis; the future of fish populations; and the effect of ocean temperature on growing seasons. Oceanographers also hope to engage other scientists and the public more deeply with ocean issues by making them more immediate. Instead of spending weeks or months on a boat gathering data, then returning to labs to make sense of it, oceanographers say they expect to be able to order up specific requests from their desktops and download the results.
Researchers will be able, for example, to assemble a year’s worth of daily data on deep ocean temperatures in the Atlantic or track changes in currents as a hurricane nears the Gulf of Mexico. And schoolchildren accustomed to dated graphics and grainy shark videos will only have to boot up to dive deep in high definition. “It’ll all go on the Internet and in as real time as possible,” said Alexandra Isern, the program director for ocean technology at the National Science Foundation. “This is really going to transform not only the way scientists do science but also the way the public can be involved.”
The program has three main parts, two of which involve placing a range of sensors in the oceans and one that connects through the Internet all the information gathered, so that the public and scientists can have access to it.
A “coastal/global” program will include stand-alone deep-water data-gathering stations far offshore, mostly in the higher latitudes of the Atlantic and Pacific, where cold, rough conditions have made ship-based oceanography difficult.
In American waters, observation systems are planned on both coasts. In the Pacific, off the Oregon coast, the system will study the upwelling of cold water that has led to repeated “dead zones” of marine life in recent summers. In the East, off Martha’s Vineyard, a coastal observation system is planned along the continental shelf, gathering information at the surface, subsurface and on the sea floor, where warm Gulf Stream currents confront colder water from off the coast of Canada.
“That mixing affects surface productivity, weather, carbon cycling,” said Robert S. Detrick, a senior scientist at Woods Hole Oceanographic Institution.
In August, the Joint Oceanographic Institutions, which is administering the Ocean Observatories Initiative for the National Science Foundation, chose Woods Hole to lead the offshore buoy and coastal program. Woods Hole, which will receive about $98 million of the total cost, will partner with the Scripps Institution of Oceanography at the University of California, San Diego, and Oregon State University’s College of Oceanic and Atmospheric Sciences.
In the Northwest, about $130 million of the initiative’s cost is being dedicated to build a regional observatory, a series of underwater cables that will crisscross the tectonic plate named for the explorer Juan de Fuca. Rather than provide an information superhighway that bypasses the ocean, this new network is being put in place to take its pulse. Professor Delaney, whose specialty is underwater volcanoes that form at the seams between tectonic plates and the surprising life those seams support, is among those who have been pursuing the cable network for more than a decade, overcoming hurdles of money, technology and skepticism.
Some scientists have suggested that the Juan de Fuca is an imperfect laboratory, that it is small and lacks some features, like the most intense El NiƱo fluctuations, that might reveal more about how that phenomenon affects conditions at sea and on land. But Professor Delaney says the Juan de Fuca plate is well-suited for the program precisely because it is self-contained, just offshore and rich with seafloor activity, complicated current patterns and abundant fish and marine mammals. The new network shares many similarities with a plan called Neptune that Professor Delaney and others began pushing for in the 1990s. As part of an earlier effort related to that project, Canada is moving forward with its own cabled network off the coast of British Columbia.
“For the first three or four years, people just laughed when I said we’re going to turn Juan de Fuca Plate into a national laboratory,” Professor Delaney said. “Now they’re not laughing.”

Many oceanographers say the program will transform their field. Oscar Schofield, a biological oceanographer at Rutgers University, has spent nearly a decade helping piece together a small-scale coastal observatory in the Atlantic using a combination of radar, remote-controlled underwater gliders and a 15-kilometer underwater cable. The program, called the Coastal Ocean Observation Lab, which he runs with Scott Glenn, also a professor at Rutgers, has a Web site where outsiders can track currents, water temperatures and salinity levels in parts of the Atlantic. They can also follow measuring instruments guided remotely from the New Jersey coast to south of the Chesapeake Bay.

Professor Schofield said that the data gathered already had upended some of what he was taught in graduate school, from the way rivers flow into the ocean to the complexity of surface currents.
“When there’s a hurricane, when all the ships are running for cover, I’m flying my gliders into the hurricane,” using his office computer, Professor Schofield said. “Then I’m sitting at home drinking a beer watching the ocean respond to a hurricane.”
He added: “What’s great about oceanography is we’re still in the phase of just basic exploration. We’ve discovered things off one of the most populated coasts in the United States that we didn’t know yet. O.O.I. will take us one level beyond that, to where any scientist in the world will be able to explore any ocean.”
Several scientists involved in the project cited improved technology — from increased bandwidth to the ability to provide constant power to instruments at sea by underwater cables or solar or wind power — as critical to making the new program possible. They also say that increased concern about global warming, storms and fisheries has brought new attention to their field.
Some experts say they wish the project included more money for, say, placing buoys in the Indian Ocean, where monsoons and other events make for rich ocean activity. But John A. Orcutt, a professor at Scripps who is directing the effort to link the new research to the Internet, said being able to provide constant new data to scientists around the world, or even to teenagers surfing YouTube, will help build support for expanding the project in the future.
“We want to get the oceans and the sea floor in front of the public now,” Professor Orcutt said, “so they can understand the need for more.”

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Saturday, September 1, 2007

Secrets Of Red Tide Revealed


Source:

Science Daily — In work that could one day help prevent millions of dollars in economic losses for seaside communities, MIT chemists have demonstrated how tiny marine organisms likely produce the red tide toxin that periodically shuts down U.S. beaches and shellfish beds.
In the Aug. 31 cover story of Science, the MIT team describes an elegant method for synthesizing the lethal components of red tides. The researchers believe their method approximates the synthesis used by algae, a reaction that chemists have tried for decades to replicate, without success.
Understanding how and why red tides occur could help scientists figure out how to prevent the blooms, which cause significant ecological and economic damage. The New England shellfish industry, for example, lost tens of millions of dollars during a 2005 outbreak, and red tide killed 30 endangered manatees off the coast of Florida this spring.
The discovery by MIT Associate Professor Timothy Jamison and graduate student Ivan Vilotijevic not only could shed light on how algae known as dinoflagellates generate red tides, but could also help speed up efforts to develop cystic fibrosis drugs from a compound closely related to the toxin. Red tides, also known as algal blooms, strike unpredictably and poison shellfish, making them dangerous for humans to eat. It is unknown what causes dinoflagellates to produce the red tide toxins, but it may be a defense mechanism, possibly provoked by changes in the tides, temperature shifts or other environmental stresses.
One of the primary toxic components of red tide is brevetoxin, a large and complex molecule that is very difficult to synthesize.
Twenty-two years ago, chemist Koji Nakanishi of Columbia University proposed a cascade, or series of chemical steps, that dinoflagellates could use to produce brevetoxin and other red tide toxins. However, chemists have been unable to demonstrate such a cascade in the laboratory, and many came to believe that the "Nakanishi Hypothesis" would never be proven.
"A lot of people thought that this type of cascade may be impossible," said Jamison. "Because Nakanishi's hypothesis accounts for so much of the complexity in these toxins, it makes a lot of sense, but there hasn't really been any evidence for it since it was first proposed."
Jamison and Vilotijevic's work offers the first evidence that Nakanishi's hypothesis is feasible. Their work could also help accelerate drug discovery efforts. Brevenal, another dinoflagellate product related to the red tide toxins, has shown potential as a powerful treatment for cystic fibrosis (CF). It can also protect against the effects of the toxins.
"Now that we can make these complex molecules quickly, we can hopefully facilitate the search for even better protective agents and even more effective CF therapies," said Jamison.
Until now, synthesizing just a few milligrams of red tide toxin or related compounds, using a non-cascade method, required dozens of person-years of effort.
The new synthesis depends on two critical factors-giving the reaction a jump start and conducting the reaction in water.
Many red tide toxins possess a long chain of six-membered rings. However, the starting materials for the cascades, epoxy alcohols, tend to form five-membered rings. To overcome that, the researchers attached a "template" six-membered ring to one end of the epoxy alcohol. That simple step effectively launches the cascade of reactions that leads to the toxin chain, known as a ladder polyether.
"The trick is to give it a little push in the right direction and get it running smoothly," said Jamison.
The researchers speculate that in dinoflagellates, the initial jump start is provided by an enzyme instead of a template.
Conducting the reaction in water is also key to a successful synthesis. Water is normally considered a poor solvent for organic reactions, so most laboratory reactions are performed in organic solvents. However, when Vilotijevic introduced water into the reaction, he noticed that it proceeded much more quickly and selectively.
Although it could be a coincidence that these cascades work best in water and that dinoflagellates are marine organisms, water may nevertheless be directly involved in the biosynthesis of the toxins or emulating an important part of it, said Jamison. Because of this result, the researchers now believe that organic chemists should routinely try certain reactions in water as well as organic solvents.
The research was funded by the National Institute of General Medical Sciences, Merck Research Laboratories, Boehringer Ingelheim, and MIT.
"This is an elegant piece of work with multiple levels of impact," said John Schwab, who manages organic chemistry research for the National Institute of General Medical Sciences. "Not only will it allow chemists to synthesize this important class of complex molecules much more easily, but it also provides key insights into how nature may make these same molecules. This is terrific bang for the taxpayers' buck!"
Note: This story has been adapted from a news release issued by Massachusetts Institute of Technology.

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