Showing posts with label Marine Biology. Show all posts
Showing posts with label Marine Biology. Show all posts

Tuesday, June 23, 2009

How Aerosols Contribute To Climate Change


ScienceDaily (June 23, 2009) — What happens in Vegas may stay in Vegas, but what happens on the way there is a different story.
As imaged by Lynn Russell, a professor of atmospheric chemistry at Scripps Institution of Oceanography at UC San Diego, and her team, air blown by winds between San Diego and Las Vegas gives the road to Sin City a distinctive look.
The team has sampled air from the tip of the Scripps Pier since last year, creating a near real-time record of what kinds of particles — from sea salt to car exhaust — are floating around at any given time. Add data about wind speed and direction and the scientists can tell where particles came from and can map their pathways around Southern California.
When Russell and her students put it all together, the atmosphere of greater San Diego comes alive in colors representing the presence of different airborne chemical compounds in aerosol form. One streak of deep red draws a distinct line from the pier that sometimes extends all the way to Las Vegas. The red denotes organic mass, a carbon-based component of vehicular and industrial emissions that pops up on Russell’s readouts frequently. Plot the streak on a road atlas and it reveals the daily life of pollution in Southern California. For one stretch of time, it neatly traced Interstate 15 all the way past the California-Nevada border.
“We were really surprised,” said Russell. “We did not expect to have such consistent winds for the selected study days.”
The hunt for various types of aerosols is helping Russell draw new kinds of global maps, ones that depict what organic compounds—whether natural or from sources such as Southern California traffic and industries—could do to affect rainfall, snowfall, atmospheric warming and cooling, and a host of other climate phenomena. Russell is part of an effort that involves several researchers at Scripps and UCSD and around the world. Collectively they are attempting to address a human-caused phenomenon in the Earth system scarcely considered before the last decade.
Aerosol research is considered one of the most critical frontiers of climate change science, much of which is devoted to the creation of accurate projections of future climate. These projections are generated by computer models — simulations of phenomena such as warming patterns, sea level fluctuations, or drought trends. The raw data for the models can come from historical records of climate basics like temperature and precipitation, but scientists often must rely on incomplete data and best guesses to represent more complex phenomena. The more such uncertainty goes into a model, the greater its margin of error becomes, making it less reliable as a guide for forecasts and adaptive actions.
Among these complex phenomena, the actions of aerosols are what some researchers consider the field’s holy grail, representing the biggest barrier to producing accurate representations of climate. In fact, the Intergovernmental Panel on Climate Change in 2007 specifically listed the effect of aerosols on cloud formation as the largest source of uncertainty in present-day climate models.
Bits of dust, sea salt, the remnants of burned wood, and even living things like bacteria all add to the mix of aerosols that create the skeletons on which clouds form. Around these particles, water and ice condense and cluster into cloud masses. The size and number of each of these droplets determine whether the clouds can produce rain or snow.
The aerosols are also influencing climate in other ways. Diesel exhaust, industrial emissions, and the smoke from burning wood and brush eject myriad bits of black carbon, usually in the form of soot, into the sky and form so-called “brown clouds” of smog. This haze has a dual heating and cooling effect. The particles absorb heat and make the air warmer at the altitudes to which they tend to rise but they also deflect sunlight back into space. This shading effect cools the planet at ground level.
The Arctic Circle is one of the places in the world most sensitive to changes in the mix of aerosols. Since the beginnings of the Industrial Revolution, scientists and explorers have noted the presence of the Arctic haze, a swirl of pollution that appears when sunlight returns after a winter of darkness. The presence of smog over a mostly uninhabited region leads many scientists to believe it is the reason the Arctic is experiencing the most rapid climate-related changes in the world. The haze now lingers for a longer period of time every year. It may be contributing to the forces now causing a meltdown of Arctic ice, a release of methane once stored in permafrost, and a host of ecological changes affecting the spectrum of organisms from mosquitoes to polar bears.
Russell has taken part in two recent analyses of polar air to understand where its imported aerosols come from and how the chemical components of those aerosols could be affecting temperature and cloud formation. From a research vessel in the Norwegian Sea and via continuous measurements from a ground station in Barrow, Alaska, Russell’s team is analyzing particles likely to have been blown to the Arctic from Europe and Asia. Her group has just compiled a full season of air samples fed through intake valves onto filters collected at Barrow.
With it, she believes she has proven what colleagues have previously theorized about where the particles are coming from. She is especially interested in organic particles—aerosols containing carbon supplied either by natural sources such as ocean or land plants or by human sources. Work in her group has shown that organics in the spring haze carry a signature consistent with dust and biomass burning taking place most likely in Siberia. The chemical signature changes in other seasons, revealing itself in infrared spectroscopy readings to be the product of aerosols from natural sources.
The aerosols could be influencing how much snowfall the Arctic gets and keeps. Human-produced aerosols are thought to stifle precipitation in some areas but may provide the impetus for torrential rain in others depending on their chemical make-up. Even if the Asian aerosols are not affecting precipitation, however, Russell said they appear to cool the Arctic atmosphere by deflecting light into space. At the same time, there is strong evidence that they are accelerating ice melt in the Arctic by darkening and heating ice once they fall to the ground the way a dark sweater makes its wearer hotter on a sunny day than does a white sweater.
Russell has been part of another collaborative effort launched in 2008, the International Polar Year, that created chemical profiles of relatively untainted air off the Norwegian west coast, which is only occasionally tinged by European smog. She has also teamed with collaborators at Scripps, NOAA and other universities to profile aerosols around Houston, Texas, and Mexico City.
In the latter two projects, she has provided evidence that agriculture adds more to the aerosol mix in an oil town like Houston than previously thought and that organic particles in Mexico City, rising from the smoke of street vendors and exhaust of cars driving on gas formulated differently than in the United States, glom on to dust in a different manner than American pollution to create aerosols with distinct chemical structures. Figuring out what they do locally and regionally is the next step.
Russell collaborates with a number of other faculty at UCSD whose research also focuses on aerosols, such as Kim Prather, an atmospheric chemistry professor with joint appointments at Scripps and the UCSD Department of Chemistry and Biochemistry. Russell and Prather are comparing their results form Mexico City in an effort to better understand the sources of aerosols in the atmosphere.
“We are trying to understand the major sources of aerosols in our atmosphere and how they affect the overall temperature of our planet; as opposed to greenhouse gases which we know are warming, aerosols can cool or warm depending on their composition and where they are located in the atmosphere," said Prather. Like Russell, Prather also studies long-range transport of aerosols from terrestrial and marine sources. Prather and Russell have worked together on several other projects and recently helped form the Aerosol Chemistry and Climate Institute, a collaboration between Scripps and the Department of Energy’s Pacific Northwest National Laboratory.
For her most comprehensive study, Russell need only to make her shortest journey to the end of Scripps Pier. It is possible that aerosol journeys of a thousand miles or more might be explained by shorter commutes between Southern California counties. Complete analysis of the Interstate 15 data suggests Vegas might not be a source of dirtiness after all. Using data collected over longer time periods, Russell’s pollution map of local counties now suggests organic human-made aerosols might just be blowing toward Nevada from San Bernardino and Riverside then back toward San Diego as winds shift. Russell employs a suite of complementary measurements at the pier to characterize short- and long-term aerosol trends. Those are combined with particle profiles made by Prather’s group and collaborators whose numbers are growing out of necessity.
“Understanding the big picture is the only way we’re going to be able to reduce the uncertainty associated with aerosol particles and their effects on climate,” said Russell. “There are so many parameters, there’s no one instrument or even one person who can do all of it at once.”
Adapted from materials provided by University of California, San Diego, via Newswise.

Friday, June 5, 2009

Height Of Large Waves Changes According To Month

SOURCE

ScienceDaily (June 2, 2009) — A team of researchers from the University of Cantabria has developed a statistical model that makes it possible to study the variability of extreme waves throughout the year. Their study has shown that there are seasonal variations in the height of waves reaching Spain's coasts, and stresses the importance of this data in planning and constructing marine infrastructures.
"Anybody who observes waves can see that they are not the same height in winter and summer, but rather that their height varies over time, and we have applied a ‘non- seasonal' statistical model in order to measure extreme events such as these," says Fernando J. Méndez, an engineer at the Institute of Environmental Hydraulics at the University of Cantabria and co-author of a study published recently in the journal Coastal Engineering.
The new model can chart the pattern of extreme waves "with a greater degree of reliability", by studying ‘significant wave height' (Hs) in relation to a specific return period. The Hs is the representative average height of the sea, provided by buoys (it is calculated by measuring one in three of the highest waves), and the return period is the average time needed for the event to happen.
For example, if a wave height of 15 metres is established at a certain point on the coast with a return period of 100 years, this means that, on average, a wave of 15 metres could reach this point once every 100 years. "This can be very useful when it comes to building an oil platform in the sea or a particular piece of coastal infrastructure", explains Méndez.
The researchers have used data recorded between 1984 and 2003 by five coastal buoys located near the cities of Bilbao, in Vizcaya; Gijón, in Asturias; La Coruña, Cádiz and Valencia in order to demonstrate the validity of their model. The results show that extreme Hs values vary according to location and the month of the year.
The meteorological component of extreme waves
The results showed a similar seasonal variation between waves in Bilbao and Gijón, with waves being less than four metres high between May and September, but increasing after this to reach an average height of seven metres between December and January. The period of large waves in La Coruña extends from October to April, because of the city's westerly position and resulting exposure to more prolonged winter storms.
The Atlantic coast of Cádiz, meanwhile, reflects the characteristic calm of this area of sea between July and September, with Hs values below two metres. The figures for December and January, however, can vary a great deal from one year to another, reaching wave heights in excess of six metres.
Waves on the Mediterranean coast at Valencia measure between 3 and 3.5 metres from September until April, although the graphics reveal two peaks during this period, one of which coincides with the start of spring and the other with the autumn months, during which the phenomenon of the gota fría occurs. (Gota fría events are atmospheric cold air pools that cause rapid, torrential and very localised downpours and high winds).
"All these data are of vital importance in terms of coastal management, since they can establish the risk of flooding and are indispensable for the carrying out of marine construction work, for example infrastructure built close to the coast," says Melisa Menéndez, another of the study's authors. "In addition, they make it possible to calculate the likelihood of a maritime storm occurring."
The researcher also stresses that this information could be very useful in helping to better understand some biological processes, such as how the distribution of marine animals is affected by wave swell, and seaweed growth rates, as well as geological processes, such as how particulates and sediments are transported along the coast.
Extreme value theory
The model developed by the Spanish scientists is based on ‘extreme value theory', a recently-developed statistical discipline that aims to quantify the random behaviour of extreme events. The latest advances in this field have made it possible to better study climatic variability at various scales - over a year (seasonality), over consecutive years or decades (which allows climatic patterns to be derived), and over the long term (providing trends).
The study into extreme waves is on the seasonal scale, but the team has also studied extreme sea level values over almost a 100-year period, thanks to data gathered during the 20th Century by a mareograph located in Newlyn, in the United Kingdom. The scientists have already started to obtain information about extreme swell and sea level values at global level as part of a United Nations project to study the sea's impacts on coasts all over the planet, and how these affect climate change.
Journal references:
Melisa Menéndez, Fernando J. Méndez, Cristina Izaguirre, Alberto Luceño e Inigo J. Losada. The influence of seasonality on estimating return values of significant wave height. Coastal Engineering, 2009; 56 (3): 211 DOI: 10.1016/j.coastaleng.2008.07.004
Melisa Menendez, Fernando J. Mendez and Inigo J. Losada. Forecasting seasonal to interannual variability in extreme sea levels. ICES Journal of Marine Science, 2009; DOI: 10.1093/icesjms/fsp095
Adapted from materials provided by Plataforma SINC, via AlphaGalileo.

Thursday, May 14, 2009

Ocean Circulation Doesn't Work As Expected

SOURCE

This model of North Atlantic currents has been called into question by new data from Duke University and the Woods Hole Oceanographic Institution. Image: Archana Gowda, Duke
(PhysOrg.com) -- The familiar model of Atlantic ocean currents that shows a discrete "conveyor belt" of deep, cold water flowing southward from the Labrador Sea is probably all wet.
New research led by Duke University and the Woods Hole Oceanographic Institution relied on an armada of sophisticated floats to show that much of this water, originating in the sea between Newfoundland and Greenland, is diverted generally eastward by the time it flows as far south as Massachusetts. From there it disburses to the depths in complex ways that are difficult to follow.
A 50-year-old model of ocean currents had shown this southbound subsurface flow of cold water forming a continuous loop with the familiar northbound flow of warm water on the surface, called the Gulf Stream.
"Everybody always thought this deep flow operated like a conveyor belt, but what we are saying is that concept doesn't hold anymore," said Duke oceanographer Susan Lozier. "So it's going to be more difficult to measure these signals in the deep ocean."
And since cold Labrador seawater is thought to influence and perhaps moderate human-caused climate change, this finding may affect the work of global warming forecasters.
"To learn more about how the cold deep waters spread, we will need to make more measurements in the deep ocean interior, not just close to the coast where we previously thought the cold water was confined," said Woods Hole's Amy Bower.
Lozier, a professor of physical oceanography at Duke's Nicholas School of the Environment and Bower, a senior scientist in the department of physical at the Woods Hole Institution, are co-principal authors of a report on the findings to be published in the May 14 issue of the research journal Nature.
Their research was supported by the National Science Foundation.
Climatologists pay attention to the Labrador Sea because it is one of the starting points of a global circulation pattern that transports cold northern water south to make the tropics a little cooler and then returns warm water at the surface, via the Gulf Stream, to moderate temperatures of northern Europe.
Since forecasters say effects of global warming are magnified at higher latitudes, that makes the Labrador Sea an added focus of attention. Surface waters there absorb heat-trapping carbon dioxide from the atmosphere. And a substantial amount of that CO2 then gets pulled underwater where it is no longer available to warm Earth's climate.
"We know that a good fraction of the human caused carbon dioxide released since the Industrial revolution is now in the deep North Atlantic" Lozier said. And going along for the ride are also climate-caused water temperature variations originating in the same Labrador Sea location.
The question is how do these climate change signals get spread further south? Oceanographers long thought all this Labrador seawater moved south along what is called the Deep Western Boundary Current (DWBC), which hugs the eastern North American continental shelf all the way to near Florida and then continues further south.
But studies in the 1990s using submersible floats that followed underwater currents "showed little evidence of southbound export of Labrador sea water within the Deep Western Boundary Current (DWBC)," said the new Nature report.
Scientists challenged those earlier studies, however, in part because the floats had to return to the surface to report their positions and observations to satellite receivers. That meant the floats' data could have been "biased by upper ocean currents when they periodically ascended," the report added.
To address those criticisms, Lozier and Bower launched 76 special Range and Fixing of Sound floats into the current south of the Labrador Sea between 2003 and 2006. Those "RAFOS" floats could stay submerged at 700 or 1,500 meters depth and still communicate their data for a range of about 1,000 kilometers using a network of special low frequency and amplitude seismic signals.
But only 8 percent of the RAFOS floats' followed the conveyor belt of the Deep Western Boundary Current, according to the Nature report. About 75 percent of them "escaped" that coast-hugging deep underwater pathway and instead drifted into the open ocean by the time they rounded the southern tail of the Grand Banks.
Eight percent "is a remarkably low number in light of the expectation that the DWBC is the dominant pathway for Labrador Sea Water," the researchers wrote.
Studies led by Lozier and other researchers had previously suggested cold northern waters might follow such "interior pathways" rather than the conveyor belt in route to subtropical regions of the North Atlantic. But "these float tracks offer the first evidence of the dominance of this pathway compared to the DWBC."
Since the RAFOS float paths could only be tracked for two years, Lozier, her graduate student Stefan Gary, and German oceanographer Claus Boning also used a modeling program to simulate the launch and dispersal of more than 7,000 virtual "efloats" from the same starting point.
"That way we could send out many more floats than we can in real life, for a longer period of time," Lozier said.
Subjecting those efloats to the same underwater dynamics as the real ones, the researchers then traced where they moved. "The spread of the model and the RAFOS float trajectories after two years is very similar," they reported.
"The new float observations and simulated float trajectories provide evidence that the southward interior pathway is more important for the transport of Labrador Sea Water through the subtropics than the DWBC, contrary to previous thinking," their report concluded.
"That means it is going to be more difficult to measure climate signals in the ," Lozier said. "We thought we could just measure them in the Deep Western Boundary Current, but we really can't."
Source: Duke University (news : web)

Thursday, September 6, 2007

‘Bringing the Ocean to the World,’ in High-Def


Source:

By WILLIAM YARDLEY
Published: September 4, 2007

SEATTLE — Thousands of miles of fiber-optic cables are strung across the world’s oceans, connecting continents like so many tin cans in this age of critical global communication. So the fact that about 800 more miles of fiber-optic cable will soon thread the sea floor off the coast of the Pacific Northwest might not seem particularly revolutionary. Until you meet John R. Delaney, part oceanographer, part oracle.
“This is a mission to Planet Ocean,” said Mr. Delaney, a professor at the University of Washington. “This is a NASA-scale mission to basically enter the Inner Space, and to be there perpetually. What we’re doing is bringing the ocean to the world.”
Under a $331 million program long dreamed of by oceanographers and being financed by the National Science Foundation, Professor Delaney and a team of scientists from several other institutions are leading the new Ocean Observatories Initiative, a multifaceted effort to study the ocean — in the ocean — through a combination of Internet-linked cables, buoys atop submerged data collection devices, robots and high-definition cameras. The first equipment is expected to be in place by 2009.
A central goal, say those involved, is to better understand how oceans affect life on land, including their role in storing carbon and in climate change; the causes of tsunamis; the future of fish populations; and the effect of ocean temperature on growing seasons. Oceanographers also hope to engage other scientists and the public more deeply with ocean issues by making them more immediate. Instead of spending weeks or months on a boat gathering data, then returning to labs to make sense of it, oceanographers say they expect to be able to order up specific requests from their desktops and download the results.
Researchers will be able, for example, to assemble a year’s worth of daily data on deep ocean temperatures in the Atlantic or track changes in currents as a hurricane nears the Gulf of Mexico. And schoolchildren accustomed to dated graphics and grainy shark videos will only have to boot up to dive deep in high definition. “It’ll all go on the Internet and in as real time as possible,” said Alexandra Isern, the program director for ocean technology at the National Science Foundation. “This is really going to transform not only the way scientists do science but also the way the public can be involved.”
The program has three main parts, two of which involve placing a range of sensors in the oceans and one that connects through the Internet all the information gathered, so that the public and scientists can have access to it.
A “coastal/global” program will include stand-alone deep-water data-gathering stations far offshore, mostly in the higher latitudes of the Atlantic and Pacific, where cold, rough conditions have made ship-based oceanography difficult.
In American waters, observation systems are planned on both coasts. In the Pacific, off the Oregon coast, the system will study the upwelling of cold water that has led to repeated “dead zones” of marine life in recent summers. In the East, off Martha’s Vineyard, a coastal observation system is planned along the continental shelf, gathering information at the surface, subsurface and on the sea floor, where warm Gulf Stream currents confront colder water from off the coast of Canada.
“That mixing affects surface productivity, weather, carbon cycling,” said Robert S. Detrick, a senior scientist at Woods Hole Oceanographic Institution.
In August, the Joint Oceanographic Institutions, which is administering the Ocean Observatories Initiative for the National Science Foundation, chose Woods Hole to lead the offshore buoy and coastal program. Woods Hole, which will receive about $98 million of the total cost, will partner with the Scripps Institution of Oceanography at the University of California, San Diego, and Oregon State University’s College of Oceanic and Atmospheric Sciences.
In the Northwest, about $130 million of the initiative’s cost is being dedicated to build a regional observatory, a series of underwater cables that will crisscross the tectonic plate named for the explorer Juan de Fuca. Rather than provide an information superhighway that bypasses the ocean, this new network is being put in place to take its pulse. Professor Delaney, whose specialty is underwater volcanoes that form at the seams between tectonic plates and the surprising life those seams support, is among those who have been pursuing the cable network for more than a decade, overcoming hurdles of money, technology and skepticism.
Some scientists have suggested that the Juan de Fuca is an imperfect laboratory, that it is small and lacks some features, like the most intense El Niño fluctuations, that might reveal more about how that phenomenon affects conditions at sea and on land. But Professor Delaney says the Juan de Fuca plate is well-suited for the program precisely because it is self-contained, just offshore and rich with seafloor activity, complicated current patterns and abundant fish and marine mammals. The new network shares many similarities with a plan called Neptune that Professor Delaney and others began pushing for in the 1990s. As part of an earlier effort related to that project, Canada is moving forward with its own cabled network off the coast of British Columbia.
“For the first three or four years, people just laughed when I said we’re going to turn Juan de Fuca Plate into a national laboratory,” Professor Delaney said. “Now they’re not laughing.”

Many oceanographers say the program will transform their field. Oscar Schofield, a biological oceanographer at Rutgers University, has spent nearly a decade helping piece together a small-scale coastal observatory in the Atlantic using a combination of radar, remote-controlled underwater gliders and a 15-kilometer underwater cable. The program, called the Coastal Ocean Observation Lab, which he runs with Scott Glenn, also a professor at Rutgers, has a Web site where outsiders can track currents, water temperatures and salinity levels in parts of the Atlantic. They can also follow measuring instruments guided remotely from the New Jersey coast to south of the Chesapeake Bay.

Professor Schofield said that the data gathered already had upended some of what he was taught in graduate school, from the way rivers flow into the ocean to the complexity of surface currents.
“When there’s a hurricane, when all the ships are running for cover, I’m flying my gliders into the hurricane,” using his office computer, Professor Schofield said. “Then I’m sitting at home drinking a beer watching the ocean respond to a hurricane.”
He added: “What’s great about oceanography is we’re still in the phase of just basic exploration. We’ve discovered things off one of the most populated coasts in the United States that we didn’t know yet. O.O.I. will take us one level beyond that, to where any scientist in the world will be able to explore any ocean.”
Several scientists involved in the project cited improved technology — from increased bandwidth to the ability to provide constant power to instruments at sea by underwater cables or solar or wind power — as critical to making the new program possible. They also say that increased concern about global warming, storms and fisheries has brought new attention to their field.
Some experts say they wish the project included more money for, say, placing buoys in the Indian Ocean, where monsoons and other events make for rich ocean activity. But John A. Orcutt, a professor at Scripps who is directing the effort to link the new research to the Internet, said being able to provide constant new data to scientists around the world, or even to teenagers surfing YouTube, will help build support for expanding the project in the future.
“We want to get the oceans and the sea floor in front of the public now,” Professor Orcutt said, “so they can understand the need for more.”

Fausto Intilla

Saturday, September 1, 2007

Secrets Of Red Tide Revealed


Source:

Science Daily — In work that could one day help prevent millions of dollars in economic losses for seaside communities, MIT chemists have demonstrated how tiny marine organisms likely produce the red tide toxin that periodically shuts down U.S. beaches and shellfish beds.
In the Aug. 31 cover story of Science, the MIT team describes an elegant method for synthesizing the lethal components of red tides. The researchers believe their method approximates the synthesis used by algae, a reaction that chemists have tried for decades to replicate, without success.
Understanding how and why red tides occur could help scientists figure out how to prevent the blooms, which cause significant ecological and economic damage. The New England shellfish industry, for example, lost tens of millions of dollars during a 2005 outbreak, and red tide killed 30 endangered manatees off the coast of Florida this spring.
The discovery by MIT Associate Professor Timothy Jamison and graduate student Ivan Vilotijevic not only could shed light on how algae known as dinoflagellates generate red tides, but could also help speed up efforts to develop cystic fibrosis drugs from a compound closely related to the toxin. Red tides, also known as algal blooms, strike unpredictably and poison shellfish, making them dangerous for humans to eat. It is unknown what causes dinoflagellates to produce the red tide toxins, but it may be a defense mechanism, possibly provoked by changes in the tides, temperature shifts or other environmental stresses.
One of the primary toxic components of red tide is brevetoxin, a large and complex molecule that is very difficult to synthesize.
Twenty-two years ago, chemist Koji Nakanishi of Columbia University proposed a cascade, or series of chemical steps, that dinoflagellates could use to produce brevetoxin and other red tide toxins. However, chemists have been unable to demonstrate such a cascade in the laboratory, and many came to believe that the "Nakanishi Hypothesis" would never be proven.
"A lot of people thought that this type of cascade may be impossible," said Jamison. "Because Nakanishi's hypothesis accounts for so much of the complexity in these toxins, it makes a lot of sense, but there hasn't really been any evidence for it since it was first proposed."
Jamison and Vilotijevic's work offers the first evidence that Nakanishi's hypothesis is feasible. Their work could also help accelerate drug discovery efforts. Brevenal, another dinoflagellate product related to the red tide toxins, has shown potential as a powerful treatment for cystic fibrosis (CF). It can also protect against the effects of the toxins.
"Now that we can make these complex molecules quickly, we can hopefully facilitate the search for even better protective agents and even more effective CF therapies," said Jamison.
Until now, synthesizing just a few milligrams of red tide toxin or related compounds, using a non-cascade method, required dozens of person-years of effort.
The new synthesis depends on two critical factors-giving the reaction a jump start and conducting the reaction in water.
Many red tide toxins possess a long chain of six-membered rings. However, the starting materials for the cascades, epoxy alcohols, tend to form five-membered rings. To overcome that, the researchers attached a "template" six-membered ring to one end of the epoxy alcohol. That simple step effectively launches the cascade of reactions that leads to the toxin chain, known as a ladder polyether.
"The trick is to give it a little push in the right direction and get it running smoothly," said Jamison.
The researchers speculate that in dinoflagellates, the initial jump start is provided by an enzyme instead of a template.
Conducting the reaction in water is also key to a successful synthesis. Water is normally considered a poor solvent for organic reactions, so most laboratory reactions are performed in organic solvents. However, when Vilotijevic introduced water into the reaction, he noticed that it proceeded much more quickly and selectively.
Although it could be a coincidence that these cascades work best in water and that dinoflagellates are marine organisms, water may nevertheless be directly involved in the biosynthesis of the toxins or emulating an important part of it, said Jamison. Because of this result, the researchers now believe that organic chemists should routinely try certain reactions in water as well as organic solvents.
The research was funded by the National Institute of General Medical Sciences, Merck Research Laboratories, Boehringer Ingelheim, and MIT.
"This is an elegant piece of work with multiple levels of impact," said John Schwab, who manages organic chemistry research for the National Institute of General Medical Sciences. "Not only will it allow chemists to synthesize this important class of complex molecules much more easily, but it also provides key insights into how nature may make these same molecules. This is terrific bang for the taxpayers' buck!"
Note: This story has been adapted from a news release issued by Massachusetts Institute of Technology.

Fausto Intilla